Sleep and Circadian Rhythm disruption are very common in ME/CFS, Long Covid and Fibromyalgia.  Circadian rhythms — the body's internal 24-hour clock — play a vital role in regulating sleep, metabolism, hormone release, and digestion. When disrupted, they can significantly affect health, particularly people with ME/CFS, Long Covid and Fibromyalgia, where sleep disturbances and fatigue are common.

Orthostatic intolerance is an umbrella term for conditions where symptoms occur when a person stands up. PoTS (Postural Orthostatic...

Explore the role of the HPA axis in chronic illness. Discover how HPA axis dysfunction affects fatigue, stress, and recovery in ME/CFS and Long Covid.

Explore how thyroid health impacts Chronic Fatigue, Long Covid, and Fibromyalgia. Discover the hidden role of the thyroid in your symptoms.

Metabolic health is a key piece in the complex puzzle of ME/CFS and Long Covid. While there is no one-size-fits-all fix, stabilising blood sugar helps to reduce inflammation and supporting your mitochondria with good food, stress management, and gentle movement can make a difference to your overall healthHere we describe what is meant by metabolic health, what can go wrong in these conditions and steps you can take to reduce high blood sugar and support your metabolism.

Discover how oxidative stress in ME/CFS and Long Covid affects energy production and symptoms. Learn strategies to reduce oxidative stress effectively.

Fructose is a sugar found in fruit and honey and also in some processed foods and sweetened drinks like coke. It sounds harmless, but eating too much fructose can be damaging, particularly in conditions like ME/CFS, Long Covid and Fibromyalgia.   Unlike glucose, fructose is absorbed in the liver and the particular way it is metabolised leads to mitochondrial stress, fat accumulation, inflammation and reduced energy levels.

One of the most challenging aspects of living with ME/CFS or Long Covid is Post-Exertional Malaise (PEM)—a worsening of symptoms following physical, cognitive, or emotional exertion. Effective management of PEM is crucial, and one of the most evidence-informed approaches is pacing. This blog explains what pacing is, why it matters, and how it can be used to support people living with ME/CFS or Long Covid.

Post exertional malaise  or PEM, is a unique type of fatigue experienced in ME/CFS and also found in Long Covid. It is a defining feature of ME/CFS and is used in the diagnosis of this condition. It is also sometimes called ”post-exertional neuroimmune exhaustion ” (PENE).  

Mitochondria—the energy factories inside our cells—play a crucial role in physical and mental stamina. For people living with conditions like ME/CFS or Long Covid, where energy production is impaired, supporting mitochondrial function can be key to symptom management. Here we describe three important nutrients that can support mitochondrial health and potentially help with fatigue: Carnitine, Iron, and CoQ10.

Fatigue is a hallmark symptom in ME/CFS and is a major symptom in Long Covid. Here we describe how energy is usually produced by the body, and then describe energy production is affected in ME/CFS and Long Covid.